As of 2019, only five space probes are leaving the solar system: Pioneer 10, Pioneer 11, Voyager 1, Voyager 2 and New Horizons. The Voyagers already left the solar system and entered the interstellar space (Voyager 1 on August 25, 2012, and Voyager 2 on November 5, 2018. The others also will leave the heliosphere ^{Notes 1} and reach the interstellar space in a few years.

All of these spacecraft are launched by NASA.